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Additionally, lacosamide, an approved drug for treating epilepsy, has also been reported to induce histone hyperacetylation via reductions of HDACs protein expressions, enhancement of histone acetyltransferase or HDAC inhibition by its metabolites [48, 49]
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Researchers may evaluate: Extracellular-matrix genes Protease-associated genes Protease-inhibitor genes Oxidative-response genes Inflammation-associated pathways Cell-cycle genes Metal-homeostasis genes Stress-response pathways Transcriptomic changes should not be described as proof of tissue renewal, rejuvenation, repair, or anti-aging activity
(9) A Nakamura, T Sugao, K Yamaue, M Kobatake, et al (1989) Involvement of spinal noradrenergic system in the mechanism of an antinociceptive effect of delta-sleep-inducing peptide (DSIP) Brain Research, 1989 Feb 20, Volume 480 (Issues 1-2), Pages 82-6
