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Schizophrenia Long-term use (up to 24 weeks) of 10003600 mg/day helped reduce negative symptoms (like low motivation, withdrawal)[1]
On the other hand, chelerythrine has other effects, for example, it can affect multiple ion channels in cardiac tissue in a pkc-independent manner (Son et al., 2011), but also anti-inflammatory effects via a pkc mechanism, with pkc acting as an upstream regulator of the pro-inflammatory PKC/NF-kappaB pathway (Zeng et al., 2015)
Pre-medication with a bronchodilator may be recommended in such cases.
P.KorkushkoO
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