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For individuals with hypertension, dyslipidemia, or metabolic syndrome, medical therapy can help reduce cardiovascular strain and increase the safety margin of surgery

Food and Drug Administration: FDAs Concerns With Unapproved GLP-1 Drugs Used for Weight Loss Harvard Health Publishing: Understanding New Weight Loss Drugs The New England Journal of Medicine : TripleHormone-Receptor Agonist Retatrutide for Obesity a Phase 2 Trial Yale Medicine: GLP-1 Weight-Loss Pills: What You Need to Know FDAs Concerns With Unapproved GLP-1 Drugs Used for Weight Loss

Although GIP receptor activation may exert anti-emetic effects through brainstem modulation, these effects appear insufficient to completely counterbalance GLP-1 mediated emesis during early treatment and dose escalation ( In contrast, glucagon receptor activation is independently associated with nausea and vomiting through both central and peripheral mechanisms, including effects on gastric motility and autonomic signaling

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