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A Phase II block is not an intentional anesthetic goal but rather an undesirable and unanticipated complication that occurs when prolonged or repeated exposure to succinylcholine, or delayed drug metabolism due to genetic or acquired pseudocholinesterase deficiency, causes desensitization of the motor endplate (Ortiz-Gmez et al., 2011
This isnt practical for individuals who suffer from chronic B12 deficiency or frequently deplete the entirety of their B12 stores
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Those studies validate the general strategy of "needle, then deliver an active into the repair window," and GHK-Cu is a mechanistically sensible candidate for that slot, but readers should not mistake evidence for the strategy as evidence for this exact pairing
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