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F.HayesM.AnsariB.ShawG.RyanA.BarryF.et al (2012)
Sex differences in psychiatric disorders have long been recognised : the Val(158)Met polymorphism in COMT is associated with obsessive-compulsive disorder in men, with anxiety phenotypes in women, and has a greater impact on cognitive function in boys than girls with COMT activity, on average, being lower in women than men due partly to its suppression by estrogen (Harrison, Tunbridge, 2008)
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Initially, the patient is recommended one shot daily for a week
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