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Additionally, caloric restriction itself may contribute to cold sensitivity

Hormonal shifts, especially during menopause, and metabolic disorders such as diabetes with autonomic neuropathy can reduce salivary output, and you should include endocrine evaluation where clinical context indicates

Initially identified as a stress-responsive protein upregulated during the unfolded protein response (UPR) and ER stress (Mungrue et al., 2009), CHAC1 plays dual roles in cellular regulation