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Timing Your Dose and Lifestyle Habits to Minimize Nausea Injecting semaglutide at night before bed allows nausea to peak while you sleep, meaning you avoid the worst symptoms during your waking hours

Abdominal pain and indigestion: These milder issues show up occasionally, affecting about 6 to 7% of users overall

Seek urgent medical assessment if you experience severe persistent abdominal pain (with or without vomiting), persistent vomiting preventing fluid intake, signs of dehydration such as dark urine or dizziness, or symptoms that do not improve after several weeks of treatment

**Shaking the vial:** Rolling gently is the correct technique