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The lack of solid clinical evidence on long-term safety, especially for ongoing use, creates uncertainty about potential interactions
Its effect is essentially eat less, delivered through a satiety pathway distinct from GLP-1
One of the hypotheses attempting to explain this is that alterations in oxidative stress mediate these effects
Using in vitro cell-based assays, the researchers found that while both peptides activated the amylin and calcitonin receptors, KBP-336 was more potent and showed a bias towards the calcitonin receptor compared to cagrilintide
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