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Results: Out of 28 family members in the study, 18 were FXII mutation carriers- seven asymptomatic males, seven females with clinic of estrogen-triggered angioedema episodes and four asymptomatic pre-pubertal girls indicating a risk for angioedema during their first ovulation

Mechanistically, molecular docking and surface plasmon resonance assays revealed that isobavachalcone directly binds estrogen receptor (ER), an NLRP3 transcription factor, thus inhibiting NLRP3 transcription and the expression of caspase 1, GSDMD and IL-1 (Wu Y

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