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For patients who have already tried GLP-1 therapy, adding an amylin pathway intervention targets different receptors and different brain regions, which is what makes the combination genuinely additive
doi: 10.1186/s40001-024-01987-1 212 WangHLiXWangQMaJGaoXWangM
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This stands in contrast to the hepatotoxicity that terminated Pfizer's danuglipron and lotiglipron programs
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