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To minimize the mislabeling of non--cell lineages during islet development, 52 we used an inducible lineage-tracing mouse model ( Ins2-DreER
MOTS-c is real biology : It is encoded within mitochondrial DNA and has been shown in laboratory studies to influence metabolic pathways such as AMPK signaling, which is involved in energy balance and insulin sensitivity
206 At typical doses, pyridoxine is readily transported across cell membranes and converted to the active form of B 6 , pyridoxal 5-phosphate (P5P)
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