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Interestingly, the benefit of liraglutide for tau phosphorylation in diabetic mice cannot be replicated by insulin treatment, suggesting that the unique neuroprotective effects of GLP-1RAs are medicated by pathways other than insulin signaling pathways [62]
In a 2022 study of tirzepatide participants who took a weekly 15 mg dose lost an average of 20.9% of their body weight over 72 weeks, compared with 3.1% in the placebo group
Diabetes, 65(4), 1023-1031
Two new drugs are showing promise for cardiometabolic benefits beyond weight loss: Orforglipron: GLP-1 medication given as a daily pill instead of a weekly injection
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