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It is clinically characterized by delayed cerebral development, cataracts, craniofacial flattening, ear and nasal deformities, delayed tooth eruption accompanied by morphological abnormalities, hearing loss, short stature, scoliosis, knee valgus, valgus foot deformity, and delayed epiphyseal development [77]
Many of these agents are produced in vivo and may be extracted from animals or humans to prepare pharmaceutical compositions
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This creates an inflammatory environment and promotes cell cycle arrest, inducing senescence in neighboring tissues 12,13
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