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The compound is a quinolinium-class structure (5-amino-1-methylquinolinium) developed as a membrane-permeable selective inhibitor of the nicotinamide N-methyltransferase enzyme
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[1] [2] Other uses include treatment for cyanide poisoning, Leber's optic atrophy, and toxic amblyopia
It was showed that NP4 treatment leaded to an increase in pro-inflammatory M1-type macrophages and a decrease in anti-inflammatory M2-type macrophages in mouse tumor tissues, with the proportion of M1 to M2 macrophages being 4.4 times higher compared to untreated mouse tumor tissues (Fig
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