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These pathways include chronic inflammation, the integrity of intestinal epithelial tight junctions, and disruptions in the gut microbiota
Various methods to inhibit the GIP system in rodents result in reduced body weight and improve insulin sensitivity ( Figure 3 Table 1 In vitro results for the most potent and widely used GIP receptor antagonists
Injectables may be reserved for acute, hospital-based situations or severe oxidative stressbut are not ideal for long-term outpatient management
This effect remains stable through the duration of treatment
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