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P-gp, an efflux transporter, actively pumps out PTX as a substrate through an ATP-dependent mechanism, thereby mediating multidrug resistance and compromising the antitumor efficacy of PTX 33,34

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The copper ion itself serves as a cofactor for lysyl oxidase, the enzyme responsible for collagen and elastin cross-linking, meaning GHK-Cu both stimulates production of new structural proteins and ensures they are properly stabilized

By contrast, suffering from hyperthyroidism means having an overactive thyroid producing an excessive amount of hormones , which is the case with Graves disease