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As the insulinotropic capacity of GLP-1 is partially retained in diabetic humans, GLP-1-based treatments have been successfully developed
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Imagine Drucker submitting a grant proposal today titled "Investigating Gila Monster Venom Proteins for Potential Therapeutic Applications." How would reviewers respond to: Unclear commercial potential No obvious connection to existing treatment paradigms High risk of "failure" (most venom studies don't yield drugs) Difficult to measure short-term impact Traditional funding metrics, publication counts, citation indices, immediate clinical relevance, would likely work against such proposals
Goiter, or thyroid enlargement, is common in people with Graves disease and can occur with other causes of hyperthyroidism as well
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