For example, a meta-analysis of 31 randomized, controlled trials reports that the most common side effects observed in the hGH studies and their respective incidences were [16]: Soft tissue edema: 50% Insulin resistance: 22% Arthralgias: 21% Carpal tunnel syndrome: 19% These side effects are transient and usually subside as the patient gets used to the therapy
Tirzepatide independently causes a modest heart rate increase, averaging 2-4 beats per minute in the SURMOUNT clinical trials
This can lead to a feeling of being backed up, even if you are eating significantly less than you were before
These drugs are not magic and carry risks - GI issues, gallbladder problems, lean mass loss if protein intake is inadequate, and long-term unknowns require thoughtful prescribing, monitoring, and integration with strength training, proper nutrition, and sleep rather than replacement of these fundamentals