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An article in the Washington Post last year indicated that 14 Anthem BCBS plans cautioned healthcare providers in several states about Ozempic prescriptions for non-diabetic patients

Figure from van der Aart-van der Beek AB, Nat Rev Nephrol, 2020 The Study Methods This was an international, event-driven, double-blind, parallel-group, randomized, placebo-controlled trial conducted at 387 sites in 28 countries comparing semaglutide to placebo in patients with T2DM and CKD, both being treated with baseline standard of care

This results in the production of deoxycholic acid, which inhibits the proliferation of pathogenic Clostridium species and reduces the production of deleterious microbial metabolites

Both treatments have their merits