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DHODH holds a pivotal position in the biosynthetic pathway of pyrimidine nucleotides, playing a crucial role in the production of DNA and RNA (49), Inhibition of DHODH disrupts this pathway, leading to abnormalities in, or cessation of, pyrimidine nucleotide synthesis
Sometimes, that acid can hurt the stomach itself, causing ulcers (which are like sores)
Finally, the peripheral inflammatory cytokines can not only cross the BBB but also bind to receptors on endothelial cells to activate the production of prostaglandins (PGs), which promotes neuroinflammation (Schiepers et al., 2005
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