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Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)
Presented for research literature review only Dancy BM et al
10.1101/gad.343129.120 7 BourgeoisB.SpreitzerE.Platero-RochartD.PaarM.ZhouQ.UsluerS.et al (2025)
in the HA-first sequence these changes were directionally similar but not statistically significant
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