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13 In addition to being recommended in patients with ASCVD, GLP-1 receptor agonists are recommended for consideration as an add-on to metformin in patients without established ASCVD in whom there is a compelling need to minimize hypoglycemia, minimize weight gain, or promote weight loss

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This energy-burning mechanism is an additional component of this therapy, which is not present in semaglutide and tirzepatide therapy