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The buccal fat pads, temples, and periorbital regions deflate, creating the "gaunt" look
CrossRef Editorial: Pharmacological and nutritional approaches to metabolic associated fatty liver disease: a step towards achieving SDG 3 Mahmut Bodur, Bojana Vidovi, Anastasios Nikolaou, Birsen Yilmaz Frontiers in Pharmacology .2026;[Epub] CrossRef Impact of newer antihyperglycemic agents on hepatic complications: A systematic review and meta-analysis of data from 5.3 million patients with type 2 diabetes mellitus Jiwon Yang, Yeongseok Hwang, Jin-Sung Ju, Seungbong Han, Jihyun An, Ju Hyun Shim Hepatology .2026;[Epub] CrossRef A novel C/EBPmiR-335-5pPRKAA2 regulatory axis drives hepatic lipid accumulation in MASLD Xiying Zeng, Yajing Xu, Sufang You, Honghong Duan, Qingyan Cai, Huibin Huang Scientific Reports .2026;[Epub] CrossRef Altered TryptophanKynurenine Pathway and Low-Grade Inflammation in Metabolic DysfunctionAssociated Steatotic Liver Disease (MASLD): Insights from LCMS/MSBased Metabolite Profiling Kbranur nal, Leyla brahimkhanl, Mehmet Emre Erol, Nemat brahimkhanl, Sabri Engin Altntop, Mahi Nur Cerit, Ethem Turgay Cerit, Halit Nahit endur International Journal of Tryptophan Research .2026;[Epub] CrossRef Modulation of metabolic, inflammatory, fibrotic, and cell death pathways by resmetirom in metabolic dysfunction-associated steatohepatitis (MASH): a transcriptomic profiling study Chen-yang He, Zhi-hua Wang, Jian-ping Weng, Hans Strijdom, Suo-wen Xu Acta Pharmacologica Sinica .2026
One major study published in early 2025, which followed over 351,000 adults, found no statistically significant increase in the long-term risk of thyroid cancer for those taking GLP-1 medications compared to those on other diabetes drugs
Lancet 1982, 2: 97
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