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Inherited metabolic diseases caused by enzymatic defects that compromise directly or indirectly the urea cycle activity are the main cause of hyperammonemia in the neonatal period

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Dosing and Administration Typical dose : 12 mg via subcutaneous injection Onset : Begins within 3060 minutes of administration Duration of action : 612 hours (individual variability may apply) Injection sites : Abdomen, thigh, or other subcutaneous regions Note : Do not exceed one dose in 24 hours

In conclusion, the complete history of GLP-1 drugs from gut hormone discovery to blockbuster therapy exemplifies the ideal arc of translational medicine