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Both treatments influence glucose metabolism and can cause gastrointestinal side effects, which may be intensified when used together
Tirzepatide activates both the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R), both class B GPCRs, though with differential potency
The practical protocol approach for most researchers starts at a lower dose, typically 2mg weekly, and escalates every three to four weeks based on tolerance
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