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The challenge historically has been that pure glucagon agonism worsens glycemia

Jeff Giullian, chief medical officer for DaVita, said at the time, adding, Based on the inclusion criteria for study participants, we believe there may be limited application of the FLOW study findings to the overall CKD patient population. He argued that the inclusion requirements necessary to partake in the FLOW trial, such as needing to be on a standard kidney disease treatment and have a certain amount of protein in the urine, were attributable to a narrow subset less than 10% of all current CKD patients

Bortolato M, Chen K, Shih JC

The best time depends on what makes you feel comfortable and keeps you on track