This needs careful evaluation and is sometimes a reason to hold off
Study: Elecoglipron, an oral small molecule GLP-1 receptor agonist in adults with obesity or overweight (VISTA): a multicentre, phase 2, randomised, placebo-controlled clinical trial
Retatrutide should not be presented as an approved weight loss medication, a guaranteed fat-loss treatment, or a replacement for nutrition, exercise, behavioral support, or medical care
Whilst it is impossible for investigators to consider all the factors at play within the package of whole diet, especially when comparing plant and animal derived proteins (Richter et al, 2015), studies consistently report that achieving adequate folate (vitamin B9) status is an important factor to mitigate the risk of homocysteine accumulation (Selhub et al, 2000