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The STEP clinical trials demonstrated that 2.4 mg once weekly achieved the greatest weight loss benefit in people with obesity, with an average loss of around 18% body weight over 68 weeks
It is rare, but the immune-modulatory effects of weight loss and hormonal changes could theoretically trigger autoimmune responses in susceptible individuals
In cases where loose skin is severe and causes physical or emotional discomfort, surgical options such as body contouring may be considered
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