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Blood collection and cell-free DNA isolation methods influence the sensitivity of liquid biopsy analysis for colorectal cancer detection
GLP-1 is a naturally occurring hormone that is released as a response to eating
[8] [9] [10] [11] Although reduced GLP-1 secretion has previously been associated with attenuated incretin effect in patients with type 2 diabetes, further research indicates that GLP-1 secretion in patients with type 2 diabetes does not differ from healthy subjects
This may explain why biomarker models based on individual microbes or metabolites often show limited external validity, and why interventions that alter microbial composition do not always yield consistent clinical benefit [485]
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