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A 2014 review in PLOS ONE noted that copper is a cofactor in several enzymes involved in IGF-1 signaling, including superoxide dismutase and lysyl oxidase
This specificity is particularly helpful in research contexts where a targeted approach is necessary to evaluate isolated physiological mechanisms
Patients with breast cancer with high expression levels of SLC3A1 expression tend to have worse prognoses across all histological grades compared with those with low SLC3A1 expression levels (49)
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