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However, when paired with potent GLP-1 and GIP agonism, the glucose-raising effect of glucagon is overridden by the insulinotropic effects of the other two pathways

A decrease in NAD+ adversely impacts cellular energy metabolism, while a reduction in SAM hinders the activation of genes that are vital for boosting metabolism

By inhibiting NNMT, the body maintains higher NAD levels, which in turn activate SIRT1, a longevity-associated gene, which may improve mitochondrial activity, fat oxidation, insulin sensitivity, and by overall energy balance