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Indefinitely, under physician supervision weight regain is common when patients stop
By activating GIP receptors, tirzepatide enhances insulin secretion in a glucose-dependent manner, meaning insulin release occurs primarily when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia
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Other tissue-specific alterations were detected, including distinct effects on hepatic and renal one-carbon metabolism, as well as region specific differences in metabolism across hippocampal and cortical parts of the brain
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