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La mayora de los estudios disponibles tienen limitaciones significativas, incluyendo tamaos de muestra pequeos (frecuentemente menos de 50 participantes), perodos de seguimiento cortos (generalmente 12-16 semanas), y falta de grupos de control adecuados
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Fan CY, Pan J, Usuda N, Yeldandi AV, Rao MS, Reddy JK (1998) Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase
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