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The most well-known examples, apart from pioglitazone, are fenofibrate, pemafibrate, seladelpar, elafibranor and lanifibranor, which have been studied in various trials regarding their effect on liver inflammation and fibrosis, without particular success, with the exception of lanifibranor, a pan-PPAR agonist, which was shown in a phase 2b RCT (NATIVE-NCT03008070) to improve ballooning and inflammation, without worsening of fibrosis
In placebo-controlled trials, patients treated with this drug had a mean increase from baseline in amylase of up to 16% and lipase of up to 39%
Can I switch compounded semaglutide providers without starting over
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