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As awareness grows that GLP-1induced weight loss can include significant muscle loss, patents have begun claiming combinations with myostatin and ActRII pathway modulators [14, 15], while scientific papers examine the mechanisms and clinical implications of body composition changes during incretin therapy [13, 23]

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Some biomarkers (oxidative stress, antioxidant capacity) may shift within 24 weeks, while functional improvements may take 812 weeks or longer depending on dose, route, and baseline status

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