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The new label includes references to some of those postmarketing risks, including intestinal obstruction, [and] severe constipation including fecal impaction. Some patients who took Zepbound have filed lawsuits, accusing Eli Lilly of failing to properly warn them that Zepbound could increase their risk of severe gut problems, including bowel obstructions, pancreatitis, and gastroparesis
In rodents, GLP-1 receptor agonists reliably stimulate calcitonin secretion through cAMP-dependent pathways
NHS Tier 3 weight management services can provide multidisciplinary support including psychological intervention, specialist dietetic input, and structured lifestyle programmes
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