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Evidence indicates that a meaningful proportion of weight reduction (~25-40%) may involve lean tissue, including skeletal muscle, particularly in the absence of adequate nutritional intake or strength training

Concomitant use of aspirin, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), warfarin, and other anti-coagulants or other drugs known to affect platelet function may add to this risk

3 Geographic variations in antileishmanial drug resistance Treatment options for leishmaniasis vary significantly by region due to differences in dominant Leishmania species and emerging drug resistance patterns (Ponte-Sucre et al., 2017)