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However, in clinical trials targeting severe cognitive impairment, chronic fatigue syndrome, or neuropathy, therapeutic doses usually range from 1,500 mg to 3,000 mg (1.5g 3g) daily

[10] Scientists conclude that that the short time course of resensitisation following acute octreotide withdrawal is suggestive of an effect(s) on receptor function or on the receptor signal transduction cascade at sites further downstream, rather than an immune-mediated phenomenon. Studies have suggested peptide-induced production of GHRH receptors, rather than a down-regulation of them

This paper is appropriately honest about its limitations

GLP-1 receptor agonists can be valuable because they may help with: lowering A1c weight reduction cardiovascular risk reduction in selected populations kidney protection in selected settings Those benefits matter because the retina does not exist in isolation