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Its essence is that the sensitivity of the target organ to insulin is reduced, so that insulin cannot normally play its physiological function to promote glucose uptake and utilization, thus causing a series of metabolic disorders (1, 2)
As noted by Hausners team: "No clinically significant pharmacokinetic or pharmacodynamic interactions were identified This suggests that no dose adjustments should be required when semaglutide is administered concomitantly with these medications." Other findings support this consistency
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For diarrhea management, psyllium is again the first choice
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