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The timepoint chosen (when drug-tolerant cells are emerging after treatment) probably contributes to this effect, and later timepoints (when cells perhaps enter senescence or other more terminally arrested states) are more likely to reflect the expected gene expression patterns
K., Davis, G., King, P
A small percentage experience persistent mild nausea, which often resolves during the next dose escalation phase or within 2 to 3 weeks of continued therapy
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