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A 2021 review published in Nutrients found that GLP-1 receptor agonist use was associated with reduced dietary intake of multiple micronutrients including B12, particularly in patients following calorie-restricted eating patterns, supporting the rationale for monitoring B12 status during treatment even in patients without pre-existing deficiency risk factors
Experimental observations indicate that AOD 9604 may affect cellular processes such as matrix synthesis and structural integrity in cartilage tissue
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