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Renal impairment GLP-1 RAs are generally safe in patients with CKD and have demonstrated nephroprotective effects in the FLOW trial, where semaglutide significantly reduced the composite renal endpoint (hospitalization for acute kidney injury, sustained 50% decline in estimated glomerular filtration rate (eGFR), end-stage kidney disease, or renal death) in patients with type 2 diabetes and CKD [15]
Veterinarski Arhiv 90:5768
Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat
Also, because GLP-1 drugs engage the brains reward circuitry the same system that governs not just craving but everyday motivation prolonged use could, in theory, dampen motivational drive in some people
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