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5 While some trials show modest weight loss, others highlight serious risks, such as ephedras cardiovascular effects, leading to its ban in multiple countries
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If weight regain plateaus at 75%, this implies users who discontinue might well achieve permanent weight loss
Licensed options in the UK include orlistat (oral), semaglutide 2.4 mg (Wegovy, approved by NICE TA875 for eligible patients), and tirzepatide (Mounjaro for type 2 diabetes
11 Marx W, McCarthy AL, Ried K, McKavanagh D, Vitetta L, Sali A, Lohning A, Isenring E
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