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At 96 hpf and 120 hpf, the morphology of heart was severely affected with the chambers which became elongated and string-like accompanied by histological changes
If future trials continue to confirm these results, retatrutide could become one of the most important therapies for obesity and metabolic disease
The ER also communicates with mitochondria via signaling from the unfolded protein response (UPR), which is activated by ER stress and signals through the three ER-resident stress sensors IRE1, PERK, and ATF6 (Walter & Ron, 2011)
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