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The results showed that after transfection with siSTAT3, GHK-Cu treatment showed a synergistic effect on the inhibition of inflammatory factors (Figures 8AE)
By antagonizing p53 activity, such as the O-GlcNAcylated c-Jun (the first discovered oncogenic transcription factor), cell death can be prevented ( Research has shown that p53 can suppress the expression of SLC7A11, a key component of the cystine/glutamate antiporter (X c system), leading to the inhibition of cystine uptake and sensitization to ferroptosis
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16 One study compared GHK-Cu dosed at 15mg/kg nasally daily for 8 weeks in mice to placebo (saline)
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