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The causal relationship reported between the unique microbial metabolic pathways found in distinct gut microbiota compositions and the long-term durability of the glycemic response to metformin monotherapy in T2D further emphasised on the interplay between metformin and gut microbiota metabolism (Foretz et al., 2023a)
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( B and C ) Feature plots for identified Reactome pathways ( B ) positively and ( C ) negatively correlated with VSMC Glp1r knockdown
In addition to LCFAs, 2-monoacylglycerol, the other component of triglycerides, can also induce GLP-1 release via G protein-coupled receptor 119 113,114,115
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