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Esposito K, Mosca C, Brancario C, Chiodini P, Ceriello A, Giugliano D

Interestingly, caspase activation by the extrinsic pathway has been reported to be able to stimulate the intrinsic pathway of apoptosis, due to the cleavage of the pro-apoptotic protein Bid into a truncated form termed tBid (Schulze-osthoff et al., 1998)

MJ: Conceptualization, Data curation, Formal Analysis, Supervision, Writing review and editing

Increasing the dose of exenatide is not recommended in patients with an estimated glomerular filtration rate (eGFR) of 30-60 mL/min/1.73 m 2 , it is contraindicated for use in patients with an eGFR of less than 30 mL/min/1.73 m 2 (123)