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In order to lower glucose, GIP travels to beta cells in the pancreas and activates GIP receptors (GIPr) via class-II G-protein coupled receptors causing an increase in intracellular cAMP and calcium leading to a release of insulin [3]

doi:10.1007/s42000-020-00210-0

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The STOP KNEE-OA trial is ongoing: 72 weeks of tirzepatide versus placebo in adults with knee osteoarthritis and obesity, with a reduction in the need for knee replacement as the main outcome

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