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Instead, paracrine interactions of alpha cells with neighbouring somatostatin-secreting delta cells may partly explain glucose-mediated regulation of glucagon secretion, as discussed in more detail below [35]

All patients were aged at least 45 years, had overweight or obesity, had ASCVD (prior heart attack, stroke or peripheral artery disease) and did not have diabetes

Khanna is with Medstar Georgetown University Hospital Department of Dermatology in Washington, District of Columbia

[7] [17] Gastrointestinal side effects including nausea, vomiting, diarrhea, constipation, and abdominal discomfort affect 2050% of patients, particularly during dose escalation periods