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Medicinal-food homology substances possess both nutritional value and therapeutic efficacy, with good safety profiles suitable for long-term application

In the peroxisome proliferator-activated receptor (PPAR)-induced COPD model, upregulation of GPX3 expression can reduce lung tissue damage caused by oxidative stress ( As mentioned earlier, the vast majority of GPX3 is secreted by the renal proximal convoluted tubules, so we speculate that the kidney may be a highly expressed organ of GPX3, and to test our hypothesis, we analyzed the GSE111159 dataset (This dataset mainly detects the gene sequencing of 10 tissues and organs of mouse kidney, liver, brain, lung, thymus, muscle, spleen, stomach, heart and testicle under physiological conditions to understand the gene expression of each tissue and organ) in the GEO database (Gene Expression Omnibus, We found that GPX3 had the highest level of expression in kidney tissue under mouse physiology (Figure 3A), which is consistent with the results of the analysis by Kim et al

Realistic Expectations: Understand that results take time, and complete whitening or dramatic changes may not be feasible for everyone

Furthermore, a clinical study revealed that oral AST supplementation provides protection against ultraviolet-induced skin injury (Figure 1, which illustrates ASTs modulation of key pathways such as Nrf2/ARE, PI3K/Akt, and NF-B in promoting neuroprotection